天游ty8线路检测中心(中国)官方网站 -Unique Platform

高通量光学生物传感装置的发展与应用

1. 基于椭偏发展无标记高通量生物互作检测仪器

2. 基于表面等离激元和相位检测发展高灵敏高通量生物互作检测仪器

3. 基于小分子微阵列进行高通量药物筛选

4. 基于生物芯片进行组学研究

1.2021年，院长奖

2. 2020年，博士毕业生朱成钢获“王大珩光学奖”

3. 2019年发表的Nature文章入选年度十大论文、

4. 2019年，博士毕业生朱成钢获“天游ty8官方网站优秀毕业生”

1996-2000, 北京师范大学物理系, 学士学位

2000-2006, 中科院物理所,博士学位

2004-2006, 美国加州大学戴维斯分校物理系,访问学者

2006-2012, 美国加州大学戴维斯分校物理系, 博士后

2012-至今，天游ty8官方网站天游线路检测中心光科系

1. 本科生必修课《光学》

2. 本科生选修课《偏振光学》

1. 1. Z.Y. Li#, C. Wang#, Z.Y. Wang#, C. G. Zhu#, J. Li, T. Sha, L.X. Ma, C. Gao, Y. Yang, Y.M. Sun, J. Wang, X.L. Sun, C.Q. Lu, M. Difiglia, Y.N. Mei, C. Ding, S. Q. Luo, Y. J. Dang, Y. Ding*, Y. Y. Fei*, B.X. Lu*, Allele-selective Lowering of Mutant HTT Protein by HTT-LC3 Linker Compounds, Nature, 575, 203-209, (2019).

2. B.L. Ge, S. Larson, H. T. Tu, Y. P. Zhao, Y. Y. Fei*, Generalized ellipsometry characterization of Ag nanorod arrays prepared by oblique angle deposition, Nanotechnology, 31, 075075, (2019).

3. H. P. Liu, H. P. Zhang, X. Y. Wu, D. P. Ma, J. H. Wu, L, Wang, Y. Jiang, Y. Y. Fei, C. G. Zhu, R. Tan, P. Jungblut, G. Pei, A. Dorhoi, Q. L. Yan, F. Zhang, R. J. Zheng, S. Y. Liu, H. J. Liang, Z. H. Liu, H. Yang, J. X. Chen, P. Wang, T. Q. Tang, W. X. Peng, Z. S. Hu, Z. Xu, X. C. Huang, J. Wang, H. H. Li, Y. L. Zhou, F. Liu, D. P. Yan, S. H. Kaufmann, C. Chen, Z. Y. Mao*, B. X. Ge*, Nuclear cGAS suppresses DNA repair and promotes tumorigenesis, Nature, 563, 131-136, (2018).

4. Z. H. Li, C. G. Zhu, Z. H. Guo, B. W. Wang, X. Wu*, Y. Y. Fei*, Highly sensitive label-free detection of small molecules with an optofluidic microbubble resonator, Micromachines, 9, 274, (2018).

5. J. W. Hu, R. Chen, C. G. Zhu, B. L. Ge, X. D. Zhu, L. Mi, J. Ma, C. Q. Han, H. Chen*, Y. Y. Fei*, Label-free microarray-based binding affinity constant measurement with modified fluidic arrangement, BioChip. J. 12, 11, (2018).

6. C. G. Zhu, G. L. Ge, R. Chen, X. D. Zhu, L. Mi, J. Ma, X. Wang, F.Y. Zheng, Y. Y. Fei*, Fast focal point correction in prism-coupled total internal reflection scanning imager using an electronically tunable lens, Sensors, 18, 524, (2018).

7. R. Chen, C. G. Zhu, G. L. Ge, X. D. Zhu, Y. S. Sun, L. Mi, J. Ma, X. Wang, Y. Y. Fei*, Detecting signals with direct Fast Fourier Transform for microarray data collection, IEEE Photonic. Tech. L. 29, 2211 (2017).

8. J. J. Wang, C. G. Zhu, D. Song, R. Q. Xia, W. Bo. Yu, Y. J. Dang. Y. Y. Fei, L.Yu, J. X. Wu, Epigallocatechin-3-gallate enhances ER stress-induced cancer cell apoptosis by directly targeting PARP16 activity, Cell Death Discovery 3, 17034 (2017).

9. C. G. Zhu, Y. Y. Fei*, X. D. Zhu, High-throughput screening based on label-free detection of small molecule microarray, Proc. SPIE 10081, 100810S (February 23, 2017); doi:10.1117/12.2246462.

10. C. G. Zhu, X. D. Zhu, J. P. Landry, Z. M. Cui, Q. F. Li, Y. J. Dang, L Mi, F. Y, Zheng and Y. Y. Fei*, Developing an efficient and general strategy for immobilization of small molecules onto microarrays using isocyanate chemistry, Sensor, 16,378,(2016).

11. C. G. Zhu, R. Chen, Y. Z. Z. Zhu, X. Wang, X. D. Zhu, L. Mi, F. Y. Zheng, Y. Y. Fei*, Calibration of oblique-incidence reflectivity difference (OI-RD) for label-free detection of molecular layer, Appl. Opt. 55, 9459 (2016).

12. X. X. Guo, Y. H. Deng, C. G. Zhu, J. L. Cai, X. D. Zhu, J. P. Landry, F. Y. Zheng, X. J. Cheng, Y. Y. Fei*, Characterization of protein expression levels with label-free detected reverse phase protein arrays, Anal. Biochem. 509, 67 (2016).

13. Y. Y. Fei*, Y. S. Sun, Y. H. Li, H. Yu, K. Lam, J. P. Landry, Z. Luo, N. Baumgarth, X. Chen and X. D. Zhu, Characterization of receptor binding profiles of influenza A viruses using a label-free glycan microarray assay platform, Biomolecules, 5, 1840, (2015).

14. Y. Y. Fei*, J. P. Lanry, Y. H. Li, H. Yu, K. Lam, S. S. Huang, H. A. Chokhawala, X. Chen and X. D. Zhu, An optics-based variable-temperature assay system for characterizing thermodynamics of biomolecular reactions on solid support, Rev. Sci. Instrum. 84, 114102, (2013).